Saturday, March 8, 2008

Saturday March 8, 2008
Response to Warfarin during Initial Anticoagulation is genes dependent !


We all are aware of situations where warfarin (coumadin) takes forever to get upto therapeutic level despite escalating dose. One study of 297 patients who were starting warfarin therapy, is published this week in The New England Journal of Medicine.

2 genotypes were assessed CYP2C9 genotypes VKORC1 haplotypes


Study found that initial variability in the INR response to warfarin was more strongly associated with genetic variability in the pharmacologic target of warfarin, VKORC1, than with CYP2C9.



Reference: click to get abstract/article

1. Genetic Determinants of Response to Warfarin during Initial Anticoagulation - Number 10, Volume 358:999-1008, March 6, 2008, The New England Journal of Medicine